• Electron Beam Sterilization of Poly(Methyl Methacrylate)—Physicochemical and Biological Aspects 

      Sharifi, Sina; Islam, Mohammad Mirazul; Sharifi, Hannah; Islam, Rakibul; Huq, Tahmida N.; Nilsson, Per; Mollnes, Tom Eirik; Tran, Khoa D.; Patzer, Corrina; Dohlman, Claes H.; Patra, Hirak K.; Paschalis, Eleftherios I.; Gonzalez-Andrades, Miguel; Chodosh, James (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-24)
      Electron beam (E-beam) irradiation is an attractive and efficient method for sterilizing clinically implantable medical devices made of natural and/or synthetic materials such as poly(methyl methacrylate) (PMMA). As ionizing irradiation can affect the physicochemical properties of PMMA, understanding the consequences of E-beam sterilization on the intrinsic properties of PMMA is vital for clinical ...
    • Sputter deposition of titanium on poly(Methyl methacrylate) enhances corneal biocompatibility 

      Sharifi, Sina; Islam, Mohammad Mirazul; Sharifi, Hannah; Islam, Rakibul; Nilsson, Per; Dohlman, Claes H.; Mollnes, Tom Eirik; Paschalis, Eleftherios I.; Chodosh, James (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-23)
      Purpose: To evaluate titanium (Ti) sputtering of the poly(methyl methacrylate) (PMMA) stem of the Boston Keratoprosthesis (BK) as a method to enhance interfacial adhesion between the PMMA and the recipient corneal tissue.<p> <p>Methods: PMMA specimens were plasma treated with Ar/O<sub>2</sub> and coated with Ti using a DC magnetron sputtering instrument. The topography and hydrophilicity of the ...
    • Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications 

      Sharifi, Sina; Islam, Mohammad Mirazul; Sharifi, Hannah; Islam, Rakibul; Koza, Darrell; Reyes-Ortega, Felisa; Alba-Molina, David; Nilsson, Per; Dohlman, Claes H.; Mollnes, Tom Eirik; Chodosh, James; Gonzalez-Andrades, Miguel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-17)
      Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility, easy processability, transparency, non-toxicity, and reasonable mechanical properties to mimic the extracellular matrix (ECM). Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular application. We ...